Nature Briefing.

"My work on quantum computing aims to solve the world's most complex problems."

Views expressed in this science and technology update are those of the reporters and correspondents.  Accessed on 13 January 2025, 1501 UTC.

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Russ Roberts (https://hawaiisciencejournal.blogspot.com).

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100

Today

A new vision for how evolution works is long overdue

by Eva Jablonka / 4h
Nature, Published online: 13 January 2025; doi:10.1038/d41586-025-00054-x The idea that evolution is driven by an organism’s development — not just the natural selection of its genes — challenges a dearly held orthodoxy among evolutionary biologists.

Yesterday

Jan 10, 2025

How the brain cleans itself during deep sleep

Brain cleanses waste during sleep
•
2d
Nature, Published online: 10 January 2025; doi:10.1038/d41586-025-00007-4 Blood vessels in the brain rhythmically constrict and dilate to drive waves of cleansing fluid through the organ.

Facebook to ditch fact-checking: what do researchers think?

by David Adam / 2d
Nature, Published online: 10 January 2025; doi:10.1038/d41586-025-00027-0 Meta’s planned shift away from third-party fact-checking in favour of a crowdsourced approach has perplexed those who study the spread of misinformation.

Jan 9, 2025

Male spiders smell with their legs

Spiders detect scents with legs
•
3d
Nature, Published online: 09 January 2025; doi:10.1038/d41586-025-00008-3 Sensory organs on the walking legs of the male wasp spider can catch the scent of a female in a mood for romance.

Jan 8, 2025

A new-year round-up of the science stories you may have missed

by Benjamin Thompson / 4d
Nature, Published online: 08 January 2025; doi:10.1038/d41586-025-00031-4 We highlight some Nature Briefing stories from the end of 2024, including the retraction saga of a controversial COVID study, the skin’s surprise immune-system and the running ability of our ancient relatives.

Ī²-C−H bond functionalization of ketones and esters by cationic Pd complexes

by Yi-Hao Li / 4d
Nature, Published online: 08 January 2025; doi:10.1038/s41586-024-08281-4 Diverse methyl Ī²-C−H functionalizations of ketones and esters are enabled by cationic Pd(II) complexes with MPANA ligands, offering access to spirocyclic and fused ring systems through enhanced catalyst–substrate affinity.

Heritable polygenic editing: the next frontier in genomic medicine?

by Peter M. Visscher / 4d
Nature, Published online: 08 January 2025; doi:10.1038/s41586-024-08300-4 We discuss the potential consequences and ethical concerns of polygenic genome editing of human embryos to alter specific variants associated with polygenic diseases, highlighting the possibility of reducing disease susceptibility while exacerbating health inequalities.

Hippocampal neuronal activity is aligned with action plans

by Ipshita Zutshi / 4d
Nature, Published online: 08 January 2025; doi:10.1038/s41586-024-08397-7 Using high-density electrophysiological recordings, how internally generated cell assemblies are updated by action plans to meet external goals is explored.

A rare PRIMER cell state in plant immunity

by Tatsuya Nobori / 4d
Nature, Published online: 08 January 2025; doi:10.1038/s41586-024-08383-z The development of a molecularly defined spatiotemporal atlas of pathogen-infected Arabidopsis thaliana leaves reveals specific cell states that have distinct roles in plant immunity.

Satellite DNA shapes dictate pericentromere packaging in female meiosis

by Damian Dudka / 4d
Nature, Published online: 08 January 2025; doi:10.1038/s41586-024-08374-0 Divergent satellite DNA shapes influence architectural protein binding and chromatin organization in two mouse species so that the satellites can be packaged and centromere function maintained, mitigating the evolutionary cost of satellite DNA expansion.

Functional evaluation and clinical classification of BRCA2 variants

by Huaizhi Huang / 4d
Nature, Published online: 08 January 2025; doi:10.1038/s41586-024-08388-8 Results from a comprehensive evaluation of the function of BRCA2 variants, particularly variants of uncertain significance, provide a useful resource to improve the clinical management of individuals who carry such genetic variants.

How frictional ruptures and earthquakes nucleate and evolve

by Shahar Gvirtzman / 4d
Nature, Published online: 08 January 2025; doi:10.1038/s41586-024-08287-y Experimental and theoretical evidence shows that incorporating finite interface widths extends fracture mechanics to include crack (and earthquake) nucleation; slow steady creep occurring at a well-defined stress threshold.

Dynamic supramolecular snub cubes

by Huang Wu / 4d
Nature, Published online: 08 January 2025; doi:10.1038/s41586-024-08266-3 Left- and right-handed snub cubes show photocontrollable elasticity and hardness, in addition to the ability to encapsulate different small molecules in distinct compartments simultaneously, with potential applications in the development of advanced biomimetic materials.

Host metabolism balances microbial regulation of bile acid signalling

by Tae Hyung Won / 4d
Nature, Published online: 08 January 2025; doi:10.1038/s41586-024-08379-9 A family of host-derived bile acid–methylcysteamine conjugates functions as FXR antagonists, forming part of a microbiota-dependent metabolic network that regulates FXR-dependent physiology.

Li2ZrF6-based electrolytes for durable lithium metal batteries

by Qingshuai Xu / 4d
Nature, Published online: 08 January 2025; doi:10.1038/s41586-024-08294-z Adding excess m-Li2ZrF6 (monoclinic) nanoparticles to a commercial LiPF6-containing carbonate electrolyte forms a stable interphase rich in t-Li2ZrF6 (trigonal), enhancing Li-ion transfer, suppressing dendrite growth and considerably improving the cycling stability of high-rate lithium metal batteries.

The sequence–structure–function relationship of intrinsic ERĪ± disorder

by Zhanwen Du / 4d
Nature, Published online: 08 January 2025; doi:10.1038/s41586-024-08400-1 Serine 118 phosphorylation drives conformational changes through the disruption of hydrophobic interactions between aromatic-rich clusters, showing how hydrophobic mutations can restore oestrogen receptor-mediated transcription.

RNA control of reverse transcription in a diversity-generating retroelement

by Sumit Handa / 4d
Nature, Published online: 08 January 2025; doi:10.1038/s41586-024-08405-w This study presents cryogenic electron microscopy structural analysis of a diversity-generating retroelement (DGR) reverse transcription system from Bordetella bacteriophage, with results indicating that RNA surrounding the

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