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Russ Roberts (https://hawaiisciencejournal.blogspot.com).
Chemists produce new-to-nature enzyme containing boron Chemists created an enzyme with boronic acid at its reactive center. This approach can produce more selective reactions with boron, and allows the use of directed evolution to improve its catalytic power. Neuropathy very common, underdiagnosed Neuropathy, the nerve damage that causes pain and numbness in the feet and hands and can eventually lead to falls, infection and even amputation, is very common and underdiagnosed, according to a new study. New insight into genesis of spina bifida Spina bifida is the most common structural disorder of the human nervous system. The causes are largely unknown, but a new study points to a link involving a chromosomal microdeletion -- and also underscores the value of folic acid as a preventive measure. 'Wraparound' implants represent new approach to treating spinal cord injuries A tiny, flexible electronic device that wraps around the spinal cord could represent a new approach to the treatment of spinal injuries, which can cause profound disability and paralysis. A team of engineers, neuroscientists and surgeons developed the devices and used them to record the nerve signals going back and forth between the brain and the spinal cord. Unlike current approaches, the new devices can record 360-degree information, giving a complete picture of spinal cord activity. Strengthening CAR-T therapy to work against solid tumors Researchers have shown that a breakthrough therapy for treating blood cancers can be adapted to treat solid tumors -- an advance that could transform cancer treatment. The promising findings involve CAR-T cell therapy, which supercharges the immune system to identify and attack cancer cells. Exercise, new drug class recommended for management of hypertrophic cardiomyopathy Experts released a new clinical guideline for effectively managing individuals diagnosed with hypertrophic cardiomyopathy (HCM). The guideline reiterates the importance of collaborative decision-making with patients who have HCM and provides updated recommendations for the most effective treatment pathways for adult and pediatric patients. Heavy snowfall and rain may contribute to some earthquakes Episodes of heavy snowfall and rain likely contributed to a swarm of earthquakes over the past several years in northern Japan, researchers find. Their study shows climate conditions could initiate some earthquakes.
Image: kckate16/Shutterstock.com Human activity is making it harder for scientists to interpret oceans' past New research shows human activity is significantly altering the ways in which marine organisms are preserved, with lasting effects that can both improve and impair the fossil record. Adolescents who view their households as more unstructured, disorganized, or hectic than their siblings develop more mental health and behavioral problems in early adulthood, according to new research. New study finds AI-generated empathy has its limits Conversational agents (CAs) such as Alexa and Siri are designed to answer questions, offer suggestions -- and even display empathy. However, new research finds they do poorly compared to humans when interpreting and exploring a user's experience. Climate resilience strategies in urban, rural areas Local decision-makers looking for ways to reduce the impact of heat waves on their communities have a valuable new capability at their disposal: a new study on vegetation resilience. Scientists completed a study of how well vegetation survived extreme heat events in both urban and rural communities across the country in recent years. The analysis informs pathways for climate mitigation, including ways to reduce the effect of urban heat islands. Pore pressure diffusion led to microseismicity at Illinois basin carbon sequestration site Pore pressure diffusion generated by carbon dioxide injected underground at a carbon storage site in the Illinois Basin is the likely cause of hundreds of microearthquakes that took place at the site between 2011 and 2012, according to a new analysis. Possible atmosphere surrounding rocky exoplanet Researchers may have detected atmospheric gases surrounding 55 Cancri e, a hot rocky exoplanet 41 light-years from Earth. This is the best evidence to date for the existence of any rocky planet atmosphere outside our solar system. Rock steady: Study reveals new mechanism to explain how continents stabilized Ancient, expansive tracts of continental crust called cratons have helped keep Earth's continents stable for billions of years, even as landmasses shift, mountains rise and oceans form. A new mechanism may explain how the cratons formed some 3 billion years ago, an enduring question in the study of Earth's history. New guidelines for depression care emphasize patient-centred approach Psychiatrists and mental health professionals have a new standard for managing major depression, thanks to refreshed clinical guidelines. Iron fingerprints in nearby active galaxy After starting science operations in February, Japan-led XRISM (X-ray Imaging and Spectroscopy Mission) studied the monster black hole at the center of galaxy NGC 4151. Researchers say future is bright for treating substance abuse through mobile health technologies Despite the high prevalence of substance abuse and its often devastating outcomes, especially among disadvantaged populations, few Americans receive treatment for substance use disorders. However, the rise of mobile health technologies can make treatments more accessible. Damaging impact of heat waves on vital organs Researchers have found evidence of the molecular causes of the damaging impact heat stress causes on the gut, liver and brain in the elderly. These findings point to the potential of developing precise prognostic and therapeutic interventions. New record holder for smallest dispersers of ingested seeds: Woodlice Even bugs as small as woodlice can disperse seeds they eat, setting a new record for smallest animal recorded to do so. The discovery underscores the crucial yet often overlooked role that small invertebrates play in ecosystems. An adjuvant made in yeast could lower vaccine cost and boost availability Adjuvants make vaccines more effective, though one of the best is an expensive extract from the soap bark tree. To lower the cost and avoid the laborious extraction process from bark, synthetic biologists introduced 38 separate genes into yeast to recreate the synthesis of the active molecule, a complex chemical, QS-21, that has a terpene core and numerous sugars. This may be the longest biosynthetic pathway ever inserted into yeast. Disorder improves battery life What determines the cycle life of batteries? And, more importantly, how can we extend it? An international research team has discovered that local disorder in the oxide cathode material increases the number of times Li-ion batteries can be charged and discharged. New target for potential leukemia therapy Investigators discovered that a subset of myeloid and lymphoid leukemias depend on a molecular complex called PI3Kgamma for survival. The study provides both mechanistic and preclinical evidence supporting the rapid initiation of clinical trials for patients with acute myeloid leukemia (AML) to test an existing medicine that inhibits the complex, called eganelisib, both alone and in combination with the most used AML chemotherapy, cytarabine. Starting people with opioid use disorder on extended-release, injectable naltrexone (XR-naltrexone) within five to seven days of seeking treatment is more effective than the standard treatment method of starting within 10-15 days, but requires closer medical supervision, according to results from a clinical trial. The findings suggest that this rapid treatment protocol could make XR-naltrexone more viable as a treatment option for opioid use disorder, which continues to take lives at an alarming rate. More than 321,000 U.S. children lost a parent to drug overdose from 2011 to 2021 An estimated 321,566 children in the United States lost a parent to drug overdose from 2011 to 2021, according to a new study. The rate of children who experienced this loss more than doubled during this period, from approximately 27 to 63 children per 100,000. The highest number of affected children were those with non-Hispanic white parents, but communities of color and tribal communities were disproportionately affected. Stilling the quantum dance of atoms Researchers have discovered a way to stop the quantum dance of atoms 'seen' by electrons in carbon-based organic molecules. This development will help improve the performance of light emitting molecules used in displays and bio-medical imaging. Scientists have confirmed the identity of an unusual, ancient and Endangered species of fish that is living in the coastal rivers of Queensland, about 1400 km north of where it was previously known to live. Acceptance of animals in urban environments How do city residents feel about animals in their immediate surroundings? A recent study shows how different the acceptance of various wild animals in urban areas is. Important factors are the places where the animals are found and their level of popularity -- squirrels and ladybugs come out on top here. The results have important implications for urban planning and nature conservation. Pressure to be 'perfect' causing burnout for parents, mental health concerns for their children Is the status of 'perfect parent' attainable? Researchers leading a national dialogue about parental burnout say 'no,' and a new study finds that pressure to try to be 'perfect' leads to unhealthy impacts on both parents and their children. Limited adaptability makes freshwater bacteria vulnerable to climate change Freshwater bacteria with small genomes frequently undergo prolonged periods of adaptive stagnation. Based on genomic analyses of samples from European lakes, researchers uncovered specific evolutionary strategies that shape these bacteria's lifestyles. Understanding the evolutionary dynamics of aquatic microbial communities is key to safeguarding ecosystem services. Gene linked to learning difficulties has direct impact on learning and memory A gene previously linked to intellectual disability has been found to regulate learning and memory in mice. Researchers have discovered a mechanism that creates memories while reducing metabolic cost, even during sleep. This efficient memory occurs in a part of the brain that is crucial for learning and memory, and where Alzheimer's disease begins. THC lingers in breastmilk with no clear peak point When breastfeeding mothers in a recent study used cannabis, its psychoactive component THC showed up in the milk they produced. The research also found that, unlike alcohol, when THC was detected in milk there was no consistent time when its concentration peaked and started to decline. Importantly, the researchers discovered that the amount of THC they detected in milk was low -- they estimated that infants received an average of 0.07 mg of THC per day. For comparison, a common low-dose edible contains 2 mg of THC. The research team stressed that it is unknown whether this amount has any impact on the infant. Swarms of miniature robots clean up microplastics and microbes, simultaneously When old food packaging, discarded children's toys and other mismanaged plastic waste break down into microplastics, they become even harder to clean up from oceans and waterways. These tiny bits of plastic also attract bacteria, including those that cause disease. Researchers describe swarms of microscale robots (microrobots) that captured bits of plastic and bacteria from water. Afterward, the bots were decontaminated and reused. Why is breaking down plant material for biofuels so slow? Tracking individual enzymes during the breakdown of cellulose for biofuel production has revealed how several roadblocks slow this process when using plant material that might otherwise go to waste. The research may lead to new ways to improve the breakdown process and make the non-edible parts of plants and other plant waste, such as forestry residue, a more competitive source of biofuels. Further ExploreVisit ScienceDaily for your latest research news. Enjoyed this newsletter? Share the knowledge with your friends and colleagues!
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