Saturday, May 18, 2024

Nature Briefing

"Found at last:  Long-lost branch of The Nile that ran by the pyramids."

Views expressed in this science and technology update are those of the reporters and correspondents.  Accessed on 19 May 2024, 0032 UTC.

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Russ Roberts (https://hawaiisciencejournal.blogspot.com).

Nature

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YESTERDAY

mRNA therapy is safe for treating the inherited metabolic condition propionic acidaemia
1d
Nature, Published online: 17 May 2024; doi:10.1038/d41586-024-01364-2 Propionic acidaemia is an inheirited metabolic condition caused by a lack of a liver enzyme, which leads to accumulation of toxic compounds. In a first-in-human trial, a therapeutic messenger RNA drug (mRNA-3927) led to restored enzyme activity, was well tolerated and showed a promising dose-dependent reduction of potentially l
Daily briefing: ‘Quantum internet’ demonstrated in three cities
by Katrina Krämer / 1d
Nature, Published online: 16 May 2024; doi:10.1038/d41586-024-01473-y Three research teams each created quantum-entangled states over several kilometres of existing optical fibres in real urban areas. Plus, lizard-inspired buildings could save lives and linguists are re-examining the idea that people are shaped by their native language.

MAY 16, 2024

Gut microbes linked to fatty diet drive tumour growth
by Gillian Dohrn / 2d
Nature, Published online: 16 May 2024; doi:10.1038/d41586-024-01443-4 Scientists know there is a link between obesity and some cancers. A study in mice and people suggests why that might be.

MAY 15, 2024

GLP-1-directed NMDA receptor antagonism for obesity treatment
by Jonas Petersen / 3d
Nature, Published online: 15 May 2024; doi:10.1038/s41586-024-07419-8 Unimolecular integration of NMDA receptor antagonism with GLP-1 receptor agonism effectively reverses obesity, hyperglycaemia and dyslipidaemia in rodent models of metabolic disease.
Dispersion-assisted high-dimensional photodetector
by Yandong Fan / 3d
Nature, Published online: 15 May 2024; doi:10.1038/s41586-024-07398-w By combining spatial and frequency dispersive thin-film interfaces with deep residual learning, a miniature photodetector allowing the acquisition of high-dimensional information on light in a single-shot fashion is described.
Evolution of a novel adrenal cell type that promotes parental care
by Natalie Niepoth / 3d
Nature, Published online: 15 May 2024; doi:10.1038/s41586-024-07423-y The adrenal gland of the oldfield mouse (Peromyscus polionotus) has a recently evolved cell type that promotes monogamous-typical parenting behaviour and is not present in closely related species.
Suppressed thermal transport in silicon nanoribbons by inhomogeneous strain
by Lin Yang / 3d
Nature, Published online: 15 May 2024; doi:10.1038/s41586-024-07390-4 We report on a method for inducing uncontaminated and precise inhomogeneous strain in nanoscale silicon ribbons and its use for determining physical effects in these strained materials, in particular, an increase in the range and control of thermal conductivity.
The rise of baobab trees in Madagascar
Baobab trees in Madagascar threatened
•
by Jun-Nan Wan / 3d
Nature, Published online: 15 May 2024; doi:10.1038/s41586-024-07447-4 We carried out genomic and ecological analyses of all eight extant baobab species, providing insights into their evolutionary history and recommendations for conservation efforts.
Arresting failure propagation in buildings through collapse isolation
by Nirvan Makoond / 3d
Nature, Published online: 15 May 2024; doi:10.1038/s41586-024-07268-5 A design approach arrests collapse propagation in buildings after major initial failures by ensuring that specific elements fail before the failure of the most important components for global stability.
Photocatalytic doping of organic semiconductors
by Wenlong Jin / 3d
Nature, Published online: 15 May 2024; doi:10.1038/s41586-024-07400-5 A previously undescribed photocatalytic approach enables the effective p-type and n-type doping of organic semiconductors at room temperature using only widely available weak dopants such as oxygen and triethylamine.
Temporal multiplexing of perception and memory codes in IT cortex
by Liang She / 3d
Nature, Published online: 15 May 2024; doi:10.1038/s41586-024-07349-5 We examined how familiar faces are encoded in inferotemporal, perirhinal and temporal pole face patches, and found that relative response magnitude to familiar versus unfamiliar faces was not a stable indicator of familiarity in any patch.
Entanglement of nanophotonic quantum memory nodes in a telecom network
Quantum internet advancements show promise
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by C. M. Knaut / 3d
Nature, Published online: 15 May 2024; doi:10.1038/s41586-024-07252-z Entanglement of two nanophotonic quantum network nodes is demonstrated through 40 km spools of low-loss fibre and a 35-km long fibre loop deployed in the Boston area urban environment.
Engineered CD47 protects T cells for enhanced antitumour immunity
by Sean A. Yamada-Hunter / 3d
Nature, Published online: 15 May 2024; doi:10.1038/s41586-024-07443-8 Combination of TCR or CAR T cells expressing the engineered CD47 variant 47E with anti-CD47 antibody therapy results in synergistic antitumour efficacy due to T cell resistance to clearance by macrophages, while maintaining macrophage recruitment into the tumour microenvironment.
Wavefunction matching for solving quantum many-body problems
by Serdar Elhatisari / 3d
Nature, Published online: 15 May 2024; doi:10.1038/s41586-024-07422-z An approach called wavefunction matching transforms particle interactions so that their wavefunctions match those of easily computable interactions, to allow for calculations of quantum many-body systems that would otherwise be difficult or impossible.
One-third of Southern Ocean productivity is supported by dust deposition
by Jakob Weis / 3d
Nature, Published online: 15 May 2024; doi:10.1038/s41586-024-07366-4 Nitrate observations over 11 years from autonomous biogeochemical ocean profiling combined with a Southern Hemisphere dust simulation find that iron supplied by dust supports about 30% of Southern Ocean productivity.
A renewably sourced, circular photopolymer resin for additive manufacturing
by Thiago O. Machado / 3d
Nature, Published online: 15 May 2024; doi:10.1038/s41586-024-07399-9 A photopolymer platform derived from renewable lipoates can be 3D-printed into high-resolution parts, which possess properties comparable to some commercial acrylic resins, and then recycled to produce a re-printable resin.
Volatile working memory representations crystallize with practice
by Arash Bellafard / 3d
Nature, Published online: 15 May 2024; doi:10.1038/s41586-024-07425-w Delay- and choice-related activities that are essential for working-memory performance drift during learning and stabilize only after several days of expert performance.
Dimerization and antidepressant recognition at noradrenaline transporter
by Heng Zhang / 3d
Nature, Published online: 15 May 2024; doi:10.1038/s41586-024-07437-6 Cryo-electron microscopy structures of the noradrenaline transporter in the apo state, bound to noradrenaline and bound to various antidepressants shed light on the substrate transport, molecular recognition and dimeric architecture of this protein.

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